Phage Therapy

Title: Phage Therapy: A revisited replacement treatment for antibiotics.
Introduction: Talk about Antibiotics and how they treat bacterial infections. Introduce the
notion of Phage therapy and talk about what it is.
Topic 1: Antibiotic resistance
1. Why is there now a need for bacteriophages.
2. Overuse of antibiotics have led to superinfections.
3. More bacteria have become resistant to antibiotics.
Topic 2: What are bacteriophages.
1. How Bacteriophages function, and why they are different from antibiotics.
2. Where do these phages come from?
3. Talk about the mechanisms in which bacteriophages infect bacteria.
4. They are living.
5. They are nonspecific.
Topic 3: Pros of Phage Therapy
1. Phage Therapy is less expensive than antibiotics.
2. The idea of phage therapy treatment is said to be less toxic, or nontoxic
3. Phage therapy is bactericidal all the time and can clear biofilms
4. It has little effect on the normal flora.
5. Being that these Phages can replicate using the systems of bacteria, there is more likely
no need for multiple doses.
Topic 4: Phages can play a role in managing and even curing some diseases.
1. Phage therapy can combat food poisoning.
2. Phage therapy can potentially combat cystic fibrosis.
Topic 5: Concerns that stem from phage therapy in humans.
1. Though they are generally nontoxic, manufacturers of these phages must be aware of
their toxins. Proper preparation for human use.
2. Isolating the right bacteriophage can be challenging; not to mention, immense testing
must occur before use.
3. Since bacteriophages can replication utilizing their host bacteria cell, how can we
control the number of phages per incident. (Possibly affecting our normal flora in the
long term)
4. What risk can these phages have on our immune system.
Conclusion: (Summarize) Talk about how great they are, while expressing your concerns. Talk
about the innovative aspect of them, if we continue to study these viruses. (Future
improvements in medicine)
Bibliography
Bardina, C, Colom, J, Spricigo, DA, Otero, J, Sánchez-Osuna, M., Cortés, P, & Llagostera, M
(2016). Gennomics of Three New Bacteriophages Useful in Biocontrol of Salmonella.
Frontiers in Microbiology, 7.
Hietala, V, Horsma-Heikkinen, J, Carron, A, Skurnik, M, & Kiljunen, S (2019). The Removal of
Endo- and Enterotoxins From Bacteriophages Preparation. Frontiers in Microbiology, 10.
Mattila, S, Ruotsalainen, P, & Jalasvuori, M (2015). On-Demand Isolation of Bacteriophages
Against Drug-Resistant Bacteria for Personalized Phage Therapy. Fontiers in
Microbiology, 6.
Międzydbrodzki, R, Górski, A, Weber-Dabrowska, B, & Fortuna, W (2007). Phage therapy of
staphlococcal infections (including MRSA) may be less expensive than antibiotic
treatment. Postepy High Med Dosw., 461-465.
Trend, S, Change, BJ, O’Dea, M, Stick, SM, Kicic, A, WAERP, . . . CF, A (2018). Use of a Primary
Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis. Frontiers in
Pharmacology, 9.
Wang, Z, Zheng, P, Ji, W, Fu, Q, Wang, H, Yan, Y, & Sun, J (2016). SLPW: A Virulent
Bacteriophage Targeting Methicillin-Resistant Staphylococcus aureus In vitro and In
vivo. Frontiers in Microbiology, 7.